Wednesday, July 9, 2014

RNA Interference Ridiculousness Alarming Boom is Over is Bust Soon

RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecules
. . . The pathway is also used as a practical tool in biotechnology, medicine and insecticides.[1]
. . . It is becoming increasingly clear that RNA binding proteins regulate posttranscriptional gene expression and play a critical role in RNA stability and translation.
. . . micronucleus test was performed to detect chromosomal damage...from spleen of rats... rats fed GM soyabean alone revealed a significant decrease in the amount of DNA...
. . . the activator binds to DNA and enables the binding of RNA polymerase.
. . . The mechanism for the decrease in the amount of DNA was discussed by Zhou et al. [27] who reported on hepatocellular degeneration, necrosis, DNA damage and the lesions of the extracellular matrix...could cause liver toxicity due to DNA strand breaks in hepatocytes.
. . . The binding of an inhibitor...alters the shape of the enzyme, resulting in a distorted active site that does not function properly.
. . . Poisons are inhibitors that bind irreversibly.

Historically, it was known by other names, including co-suppression, post transcriptional gene silencing (PTGS), and quelling. Only after these apparently unrelated processes were fully understood did it become clear that they all described the RNAi phenomenon.

USDA: RNA-interference Pesticides Will Need Special Safety Testing
http://www.gmoevidence.com/usda-rna-interference-pesticides-will-need-special-safety-testing/

The Effect of Extra Virgin Olive Oil and Soybean on DNA, Cytogenicity and Some Antioxidant Enzymes in Rats
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073157/

Photo: RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecules
. . . The pathway is also used as a practical tool in biotechnology, medicine and insecticides.[1] 
. . .  It is becoming increasingly clear that RNA binding proteins regulate posttranscriptional gene expression and play a critical role in RNA stability and translation. 
. . .  micronucleus test was performed to detect chromosomal damage...from spleen of rats... rats fed GM soyabean alone revealed a significant decrease in the amount of DNA...
. . . the activator binds to DNA and enables the binding of RNA polymerase.   
. . . The mechanism for the decrease in the amount of DNA was discussed by Zhou et al. [27] who reported on hepatocellular degeneration, necrosis, DNA damage and the lesions of the extracellular matrix...could cause liver toxicity due to DNA strand breaks in hepatocytes. 
. . . The binding of an inhibitor...alters the shape of the enzyme, resulting in a distorted active site that does not function properly.
. . .  Poisons are inhibitors that bind irreversibly.

Historically, it was known by other names, including co-suppression, post transcriptional gene silencing (PTGS), and quelling. Only after these apparently unrelated processes were fully understood did it become clear that they all described the RNAi phenomenon.

#MONSANTO #RNAi 

USDA: RNA-interference Pesticides Will Need Special Safety Testing
http://www.gmoevidence.com/usda-rna-interference-pesticides-will-need-special-safety-testing/

The Effect of Extra Virgin Olive Oil and Soybean on DNA, Cytogenicity and Some Antioxidant Enzymes in Rats 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073157/

The elephant is in the room.
We will all be squished...

...by feeding as a dietary component.
Feasibility, limitation and possible solutions of RNAi-based technology for insect pest control.

"Numerous studies indicate that target gene silencing by RNA interference (RNAi) could lead to insect death. This phenomenon has been considered as a potential strategy for insect pest control, and it is termed RNAi-mediated crop protection. However, there are many limitations using RNAi-based technology for pest control, with the effectiveness target gene selection and reliable double-strand RNA (dsRNA) delivery being two of the major challenges. With respect to target gene selection, at present, the use of homologous genes and genome-scale high-throughput screening are the main strategies adopted by researchers. Once the target gene is identified, dsRNA can be delivered by micro-injection or by feeding as a dietary component."
http://www.pubfacts.com/detail/23955822/Feasibility-limitation-and-possible-solutions-of-RNAi-based-technology-for-insect-pest-control.

very specific ?
...for use in potential plant-based RNAi control strategies. Delivery of dsRNA expressed by genetically modified crops to the midgut of phytophagous insects is under investigation as a new tool for very specific protection of plants from insect pest species. The T. castaneum screening platform offers a system for discovery of candidate genes with high potential benefit.

Photo: THIS SAYS IT ALL!!

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