Tuesday, August 19, 2014

Auto-Immune Antiphospholipid Cause and Other GMO Illnesses

Round-Up resistant crops are made by inserting a portion of DNA into the food, and that DNA comes from a type of bacteria that is resistant to Round-Up. While this genetic modification is successful in its primary goal of making food that is resistant to Round-Up, we do have a big problem if the mechanism of resistance involves an expression of any of the negatively charged proteins or lipids from the bacteria, on the outside of the plant cell.

For more than a year I did extensive study on the antimicrobial peptide mimic, CSA-13; it is a synthetic biomimetic compound that is active in the body much like ll-37.

CSA-13 has a strongly cationic (positively charged) head-group and a hydrophobic tail, but to make a long-story short: it is electrically attracted to the anionic (negatively charged) expression of pathogen membranes, whether that is the LTA, LPS, or the lipid bilayer of the membrane itself.

Once CSA-13 is attached, the hydrophobic tail inserts itself into the cell causing blebbing, apoptosis and cell death. MRSA, drug-resistant pseudomonas, and even multiple myeloma cells are utterly destroyed by this compound. It was my responsibility to understand, research, and characterize the membrane depolarization mechanisms of the compound.

Those negatively charged outer portions of the pathogens are what trigger the human immune response. The immune system is necessary in that can help us 'get better,' but it is not exactly 'healthy' to have this immune response triggered.

When the immune response is triggered, it is stressful to nearly every organ of the body. If the resistance to Round-Up is as previously described, then there is the possibility that these specific GM foods are subtle triggers of the human immune system; causing inflammation and potentially worse,unforeseen consequences...
(0:28) This article is 100% biased in favor of Monsanto's GMOs. So please, allow me a rapid fire counter-point:

(0:36) There may be no short-term negative health effects of GMOs, and if they'd been brought before the FDA anytime other than the deregulate-happy early 90's they'd have had to prove a bit more.

(0:45) There is one bacteria that's resistant to Round-Up, so they put its gene in our food. The problem is that the anionic outer membrane lipids are the gatekeepers, likely what we modified with bacterial DNA.

(0:56) And bacterial teichoic acids, and lipopolysaccharides, are what signal the human immune response and make us present 'sick symptoms' as we fight the bacteria. So now we get multiple daily doses of immune stress ingredients, which stresses out our whole body over our entire lives.

(1:12) Worst of all, these anionic immune stimulators are hidden in the zwitterionic membrane environment of our food; leaving the total membrane net neutral and effectively invisible to our cationic peptides and everything else that would fix the problem.

For those in the field, what happens when ll-37 is over-expressed in the bloodstream? What happens when they can't find a pathogen? Do they not lyse erythrocytes? Do they not destroy red blood cells? I know this because CSA-13 can do the same thing, although not nearly as much as ll-37, which makes it a good compound for study against pathogens.

I'll assume the professionals have made the mental leap already, so, let me spell it out for everyone else: not only are Round-Up resistant crops potential stressors for the body in small amounts, bit by bit over time, but when they trigger the immune response, it causes our peptides to go on the offensive; looking to kill.

The problem is that food cells express zwitterionic membranes (positive-negative-positive-negative) and as a whole, appear electrically neutral. This means that our peptides won't be able to find them, they won't have any 'bad' cells to attack, so, what is left? Red blood cells.

From there, you get into cytotoxic elements of the cell interiors that are perfectly fine inside the cell, but bad news if allowed to float freely in the bloodstream.

Round-Up resistant crops passed regulation on what is basically a "substantial equivalent" basis from the FDA. This was during Reagan's deregulation push, and the process is laughably less rigorous than EVERY standard through which drugs and devices are now forced to pass.

This is an unacceptable risk given the subject matter: food. It is also a legitimate concern given basic microbiology. This letter does not definitively prove anything, but it is imperative that further studies are conducted.

This author recommends a gene array analyses to ascertain all the subtle effects of the resistant expression of those foods, there are number of laboratories that can easily perform one; it may be as simple as that.

- Ben Davidson, JD

Where can you learn more about the information discussed in this article?

'Alberts Molecular Biology of the Cell.' 4th Ed. ©2002 New York, Garland Science.

Boman HG. 'Antibacterial Peptides: Basic facts and emerging concepts.' J Intern Med 2003; 254: 197-215.

Garimella et al. 'Conformation of the phosphate D-alanine zwitterion in bacterial teichoic acid from nuclear magnetic resonance spectroscopy.' Biochemistry, October 2009.

Glukhov et al. 'Basis for Selectivity of Cationic Antimicrobial Peptides for Bacterial Versus Mammalian Membranes.' J Biol Chem, October 2005.

Kim J. (July 1991) 'Binding of peptides with basic residues to membranes containing acidic phospholipids.' Biophys J. 60 (1): 135-48.

Matsuzaki et al. 'Molecular Basis for Membrane Selectivity of an Antimicrobial Peptide, magainin 2.' Biochemistry, March 1995.

Nan et al. 'Prokaryotic selectivity and LPS-netralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37.' Peptides. June 2012.

Vance, DE. 'Biochemistry of Lipids, Lipoproteins and Membranes.' Elsevier. pp. 80-81. ISBN 0-444-89321-0.

Yeagle, P. 'The Membranes of Cells.' 2nd Ed. ©1993 Boston: Academic Press.

Fractals. It means that basic patterns repeat all throughout nature. It can be seen in branching veins in the human body, tributaries and streams of a river, and in this case, trees and human placentas. Essentially, the idea is that things will tend to branch out into new things as they continue on with natural processes.

Fractal nature...This is why messing with the tree of life is so wrong...DNA and RNA manipulation is the tree in the Bible and, a warning from the past...
The message just got mixed up...

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